FIELD: organic chemistry. SUBSTANCE: product: amides of the formula (I): 
where: a): E - nitrogen and X - phenylsulfonyl; b): E - group CZ where C - ring carbon atom; Z - hydrogen, cyano-group, halogen, hydroxyl, alkyl or alkoxyl; X - phenylcarbonyl, phenylsulfinyl or phenyl sulfonyl; c): X - cyano-group and Z - phenylsulfonyl; R2 and R3 free alkyl or alkyl substituted with fluorine or they together form 3-5-membered cycloalkyl, and pharmcomposition based on amides of the formula (I) and methods of amide synthesis. Method 1. Reagent 1: the corresponding aniline. Reagent 2: the corresponding acid. Method 2. Reagent 1: amide of the formula (I) containing hydroxyl-protected group. Reaction condition: protective group removing. Method 3. Reagent 1: amide of the formula (I) where X - phenyl sulfide. Reagent 2: oxidizing agent. Synthesized compounds can be used in medicine. EFFECT: improved method of synthesis. 6 cl, 2 tbl
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