DERIVATIVES OF 4-PHENYLMETHYL-1H-INDOLE AS ENANTIOMERS, RACEMATES OR DIASTEREOISOMERS OR AS ACID-ADDITIVE SALTS SHOWING ANTIARRHYTHMIC AND ANTICALCIUM ACTIVITY Russian patent published in 1996 - IPC

FIELD: organic chemistry. SUBSTANCE: products: derivatives of 4-phenylmethyl-1H-indole of the formula (I) where R and R₁ are similar or different: hydrogen, lower alkyl or cycloalkyl with 6 carbon atoms, or R and R₁ together with nitrogen atom form piperazinyl substituted with lower alkyl, A-(CH₂)_n,, where n - whole number 2 or 3, or -CH₂-CH(OH)-CH₂-; Z - hydrogen, lower alkyl or aminoalkyl-R₂NH₂, where R₂ - lower alkylene; X and Y - hydrogen atoms or one - hydrogen and other is C₁-C₄-alkyl or hydroxy-group; a, b, c and d - either b and c form double bond, a and d - hydrogens, or a and b form oxo-group and c and d - hydrogens. Reagent 1: compound of the formula (II) . Reagent 2: compound of the formula (III) where M - lithium or magnesium, Hal - halogen. Reaction conditions: in organic solvent medium, at 0-5 C. Synthesized compounds were used in medicine. ???EFFECT: improved method of synthesis. 4 tbl