FIELD: organic chemistry. SUBSTANCE: product: 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid (4R-cis)-1,1-dimethylethyl ester, empirical formula is 
, m. p. is 67.2-69.7 C. Reagent 1: 2,2-dimethyl-1,3-dioxane-4-acetic acid (4R-cis)-1,1-dimethylethyl ester of the formula (II) 
where L - halogen atom or group of the formula (IIa) where Ar - phenyl substituted with one or two substituents from halogen number atom or nitro-group. Reagent 2: compound of the formula (III) where M - alkaline metal atom. Process conditions: at 0-100 C in solvent medium. Compound of the formula (I) is the raw for synthesis of 6-(2-aminiethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid (4R-cis)-1,1-dimethylethyl ester which is an intermediate compound for synthesis of cholesterol biosynthesis inhibitors. ???EFFECT: improved method of synthesis.
| Title |
Year |
Author |
Number |
| METHOD OF PREPARING TRANS-6-[SUBSTITUTED PYRROL-1- YL)ALKYL]PYRAN-2-ON DERIVATIVES AND THEIR DIHYDROXY-CONTAINING ACIDS AND SALTS, HYDROXY-, 1,3-DIOXAN- OR PYRROLE-CONTAINING CARBOXYLIC ACIDS AS INTERMEDIATES FOR PREPARING SAID PYRAN-2-ON DERIVATIVES |
1994 |
- Donal'D Ehjdzhin Batler
- Tung Van Li
- Tomas Norman Nanninga
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| ARYLTHIOCOMPOUNDS, METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITION |
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- Dzhon Majkl Domadzhela
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- Om Prakash Goehl[Us]
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1993 |
- Tung Ven Li[Us]
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| AMINOACETIC ACID DERIVATIVES AS RACEMATES OR D-AND L- ENANTIOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD OF PREPARING D-AND L-ENANTIOMERS OF AMINOACETIC ACID DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND AMINOACETIC ACID D-AND L-ENANTIOMERS AS CINCHONIDINE SALTS |
1993 |
- Vladimir Bajlin[Ua]
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|
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- Milton Luis Khoufl
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SU1241988A3 |
| DERIVATIVES OF 3-ALKYLHYDROXY-, ARYLHYDROXY- OR ARYLALKYLHYDROXY[B]THIOPHENE-2-CARBOXAMIDE, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY INHIBITING ADHESION OF LEUKOCYTES TO VASCULAR ENDOTHELIUM |
1993 |
- Dajen Khehrris Boskelli
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RU2117665C1 |
| SULFAMIC ACID ESTERS, PHARMACEUTICAL COMPOSITION FOR CONTROL OF CHOLESTEROL CONCENTRATION, METHOD OF TREATMENT OF PATIENTS WITH HYPERCHOLESTEROLEMIA, METHOD OF TREATMENT OF PATIENTS WITH ATHEROSCLEROSIS |
1994 |
- Khelen Tsenvej Li
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- Vendell Virendzhe
|
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| DERIVATIVES OF BENZOTHIAZINE DIOXIDE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF SHOWING INHIBITORY ACTIVITY OF ENDOTHELIN RECEPTOR AND METHOD OF INHIBITION OF ENDOTHELIN RECEPTOR |
1996 |
- Kent Ehlen Berrimehn
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