VASOTOCIN DERIVATIVES Russian patent published in 1996 - IPC

FIELD: medicine, biotechnology. SUBSTANCE: derivatives of vasotocin of the formula where Y - homoglutamine or homocitrulline; X - -HN-CH(CO)(CH₂)_nNHQ; n = 1-3; Q - H, alanyl or L-2-aminobutyric acid. All derivatives of vasotocin were synthesized on applied biosystem 430A of peptide synthesizer using double connective program including the end-step after the second connection. Structure of the end peptide is confirmed by amino acid analysis and mass-spectrometry. EFFECT: improved method of synthesis. 1 tbl