FIELD: organic chemistry, pharmaceutical industry. SUBSTANCE: desired product has formula 
where R1 is cyanoalkyl, substituted or unsubstituted cycloalkyl, halogenated lower alkyl, alkynyl or tetrahydro-4H-pyran, R2 is amino or acyl amino group, R3 is halogen, X is -NH- group, Z is =N-CH3 or (CH3)O. Suitable derivative of benzoic acid is used as reagent 1, amino derivative of bicyclo[3.2.1]octane is used as reagent 2. Reaction is carried out in aqueous solution of sodium hydroxide in the presence of pyridine at room temperature. EFFECT: improves quality of desired product. 4 tbl
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