FIELD: medicine.
SUBSTANCE: invention relates to compound of structural formula
,
possessing antagonistic activity with respect to orexin receptor. In formula (IV) Q represents -CH- or nitrogen atom, each of R1a and R1b independently represents C1-6alkyl group, halogen-C1-6alkyl group, hydroxy-C1-6alkyl group or C1-6alkoxy-C1-6alkyl group, R1c represents hydrogen atom or hydroxyl group, each of R2a, R2b, R2c and R2d independently represents hydrogen atom, halogen atom, hydroxyl group, C1-6alkyl group, C1-6alkoxygroup or halogen-C1-6alkyl group or cyano-group, and each of R3a, R3b, R3c and R3d independently represents hydrogen atom, halogen atom, hydroxyl group, C1-6alkyl group, C1-6alkoxygroup, halogen-C1-6alkyl group, C1-6alkoxy-C1-6alkyl group, cyano-group or cyano-C1-6alkyl group.
EFFECT: increased treatment efficiency.
20 cl, 1 dwg, 75 tbl, 327 ex
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