METHOD OF DIAGNOSIS OF INITIAL STAGES OF CHRONIC RENAL FAILURE Russian patent published in 1996 - IPC

FIELD: medicine, nephrology. SUBSTANCE: method involves estimation of blood and urine biochemical parameters reflecting osmos-regulating function of kidney: concentration of osmotically active substances (U_OSm, P_OSm, /кг H₂O), creatinine concentration (U_Сr, P_Cr, mM), urea (U_Ur, P_Ur, mM). sodium (U_Na+, P_Na+, mM), potassium (U_K+, P_K+, mM). Based on this data the following indices were calculated: concentration index (U/P), osmotic clearance (C_OCm, ml/min), clearances of creatinine (C_Cr, ml/min), urea (C_Ur, ml/min), sodium (C_Na+, ml/min), potassium (C_K+, ml/min), excreted and reabsorbed fractions of osmotically active substances (EF, RF %), clearance of osmotically free water (, ml/min). Results were evaluated and compared with the initial values determined under usual conditions. EFFECT: detection of initial stages of chronic renal failure in patients with kidney pathology, improved method of diagnosis.