FIELD: medicine.
SUBSTANCE: invention refers to medicine, experimental biology, ecology, toxicology and can be used for simulating chronic toxic nephropathy in experimental animals. Method for simulating chronic toxic nephropathy in rats involves experimentally administering a toxic substance to an experimental animal, wherein the toxic substance used is a potassium dichromate solution administered through a probe into the stomach once a day daily for two months in dose of 0.5 mg/kg in terms of a metal, where per unit of the solution equal to 0.5 ml, 0.05 mg of chromium.
EFFECT: method provides developing nephropathy in an animal due to the optimal dose and length of exposure to metal, which can be used when searching for agents for preventing and treating said pathology.
1 cl, 2 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF CHROMIUM IN RATS IN EXPERIMENT | 2022 |
|
RU2793548C1 |
| METHOD FOR THE PREVENTION OF ALCOHOL-INDUCED NEPHROPATHY ON THE BACKGROUND OF LEAD INTOXICATION IN RATS IN THE EXPERIMENT | 2022 |
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|
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| METHOD FOR MODELING OF CHRONIC TOXIC NEPHROPATHY IN EXPERIMENTAL ANIMALS | 2022 |
|
RU2793544C1 |
| METHOD FOR SIMULATING CHRONIC ALCOHOL INTOXICATION IN EXPERIMENTAL RATS | 2020 |
|
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| METHOD FOR PREVENTION OF NEPHROTOXIC ACTION OF ANTIMONY IN RATS IN EXPERIMENT | 2023 |
|
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| METHOD FOR PREVENTION OF NEPHROTOXIC EFFECT OF MOLYBDENUM | 2020 |
|
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| METHOD OF REDUCING NEPHROTOXICITY OF AMMONIUM MOLYBDATE | 2015 |
|
RU2588319C1 |
| METHOD FOR PREVENTION OF TOXIC COAGULOPATHY IN RATS | 2022 |
|
RU2794030C1 |
| METHOD FOR SIMULATING CHROMIUM-INDUCED COAGULOPATHY IN EXPERIMENTAL RATS | 2020 |
|
RU2743812C1 |
