METHOD OF SYNTHESIS OF ARYLHYDROXYPROPYLENE-PIPERAZINYLACETANILIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE ESTERS OR ACID-ADDITIVE SALTS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: compound of the formula (I) $$$ where $$$ - hydrogen, lower alkyl or alkoxy; $$$ - hydrogen, lower alkylthio or alkoxy, halide or trifluoromethyl; $$$ - hydrogen, lower alkyl, alkoxy, halide or CN; $$$ - hydrogen, lower alkoxy; $$$ - hydrogen, lower alkyl; $$$ - hydrogen, lower alkyl, acyl or alkoxy; $$$ - hydrogen, lower alkoxy, trifluoromethyl, halogen or together with $$$ - the group CH=CH-CH= CH-; $$$ - hydrogen, lower alkyl, alkoxy, aminocarbonylmethyl, CN, halide, dialkylamino-group; $$$ and $$$ - hydrogen, alkoxy; $$$ and $$$ - hydrogen, alkyl; W - oxygen. Reagent 1: piperazine derivatives involving one of the side-chain of compound of the formula (I) $$$. Reagent 2: source of other side-chain. Synthesized compounds were used in cardiology. EFFECT: improved method of synthesis, enhanced effectiveness of treatment.