DERIVATIVES OF 10,11-METHANEDIBENZOSUBERANE, CHEMOSENSIBILIZING COMPOSITION, METHOD RESISTANCE TO ANTITUMOR DRUG OVERCOMING AND METHOD OF TREATMENT OF PATIENTS WITH TUMOR DISEASES Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to pharmaceutically active agents. Invention describes derivative of 10,11-methanedibenzosuberane of the general formula (I) where A means where R^a means H, OH or lower acyloxy-group or where one of R^a or R^b means H, OH or lower acyloxy-group and other means H; means H, F, Cl or Br; means H, F, Cl or Br; R³ means heteroaryl-group consisting of two condensed rings containing from 1 to 3 heteroatoms taken among N, O or S, or their pharmaceutically acceptable salts. These compounds show antitumor activity and are useful for treatment of oncological patients, in part, for enhancement of conceptional methods of cancer chemotherapy and for prophylaxis of resistance to a great number of drugs. Invention describes also method of overcoming the resistance to antitumor drugs and method of treatment of oncological patients. EFFECT: improved method of treatment. 17 cl