METHOD OF PREPARING THE ARTIFICIAL OXYGEN CARRIER Russian patent published in 1997 - IPC

Abstract RU 2072853 C1

FIELD: medicine, hematology. SUBSTANCE: invention relates to making donor blood erythrocyte substituent based on chemically modified extraerythrocyte hemoglobin. Method involves deoxygenation of 8-10% hemoglobin solution containing 4-5-fold molar excess of pyridoxal-5-phosphate followed by its polymerization with glutaric aldehyde and hydrogenation. The obtained product is dialyzed against saline solution and subjected for sterile filtration. The obtained polyhemoglobin does not show by-side negative action on animal organism. EFFECT: improved method of oxygen carrier preparing, high effectiveness of preparation. 2 tbl

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RU 2 072 853 C1

Authors

Azhigirova M.A.

Vashkevich M.G.

Vjazova E.P.

Litvinenko Ju.A.

Dates

1997-02-10—Published

1990-01-02—Filed