PROCESS FOR PREPARING 4-AMINO-3-PHENYLBUTANIC ACID HYDROCHLORIDE Russian patent published in 1997 - IPC

Abstract RU 2072984 C1

FIELD: medicine used as tranquilizer. SUBSTANCE: styrene. Reagent 2: sodium nitrate. Reaction conditions: at molar ratio of 1:2.2 in organic solvent in the presence of mineral acid at 0-10 C followed by boiling the resulting dimer of alpha-nitroso-beta- nitroethylbenzene in lower aliphatic alcohol in the presence of catalytic amount of triethylamine followed by addition of methanol, and condensation is carried out in the presence of sodium hydroxide at molar ratio of beta- nitro-styrene to malonic ester to sodium hydroxide of 1.0:1.3-1.0, and treatment involves the use of concentrated hydrochloric acid in amount 7-12 moles per mole of the reducing product. EFFECT: improved properties of the title compound.

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RU 2 072 984 C1

Authors

Smirnov S.P.

Abdrakhmanov I.Sh.

Khisamutdinov G.Kh.

Mratkhuzina T.A.

Tkacheva E.B.

Zobacheva M.M.

Vasil'Eva O.S.

Dates

1997-02-10Published

1993-04-28Filed