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2 073 667

(13)

(51)

IPC

(21) (22)

Application

5010153/04, 1991-10-29

(22)

Actual filing date

1991-10-29

(45)

Published

1997-02-20

(72)

Inventor

Filip Tomas Khambleton[Gb]Charl'Z Dzhon Robert Khedzhekok[Gb]Devid Pol Kej[Gb]Ehlizabet Ann Kuo[Gb]Vil'Fred Rodzher Tulli[Gb]

(73)

Holder

Russel'-Juklaf

3-CYCLOALKYLPROPANEAMIDES SHOWING ANTIINFLAMMATORY AND IMMUNOSUPPRESSING ACTIVITY, METHOD OF THEIR SYNTHESIS, CYANAMIDE AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

Abstract RU 2073667 C1

FIELD: organic chemistry. SUBSTANCE: product: 1-(4-trifluoromethylphenylcarbamoyl)-2-cyclopropyl-2-oxopropionitrile, m. p. is 212-213 C. Compounds were synthesized by interaction of the corresponding amine with organic acid to synthesized cyanomethylamide which is treated successively with sodium hydride in the presence of catalyst if necessary (imidazole) followed by with compound Hal-CO-R and isolation of the end product. Synthesized compounds were used as drugs. EFFECT: improved method of synthesis. 2 tbl

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RU 2 073 667 C1

Authors

Filip Tomas Khambleton[Gb]

Charl'Z Dzhon Robert Khedzhekok[Gb]

Devid Pol Kej[Gb]

Ehlizabet Ann Kuo[Gb]

Vil'Fred Rodzher Tulli[Gb]

Dates

1997-02-20—Published

1991-10-29—Filed