DERIVATIVES OF 3-CYCLOALKYLPROPENE-2-AMIDE OR THEIR ADDITIVE SALTS WITH MINERAL OR ORGANIC BASES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIINFLAMMATORY ACTIVITY Russian patent published in 1997 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: product: derivatives of 3-cycloalkylpropene-3-amide of the general formula (I) where: A - residue ; R₁ - H; W - O, S, SO₂; Y and Z - CH= or one of Y and Z - and other - N; R₂-R₆ - H, halide, alkyl-C₁-C₄,CH₃O,CH₃,WCCF₃,CF₃,NO₂, CN, N(CH₂)_nCF₃W(CF₂)_nCF₃ where W - as indicated above; n = 1, 2, 3 or group -(CH₂)_nCX₃ where X - halide, n - as indicated above; or R₃ and R₄ - together the group -OCH₂O- and R₂,R₅R₆ - as indicated above; R₇ and R₈ - H, alkyl-C₁-C₆; R₉ - cycloalkyl-C₃-C₆, or their salts with mineral or organic acids and pharmcomposition containing (I) at effective amount. Synthesis: reagent 1 where A - H; reagent 2: HO-CO--CH₂CN and compound (I) is synthesized where A - that is subjected for preliminary reaction with sodium hydride and then with compound HalCOR₉. EFFECT: improved method of synthesis. 25 ex, 1 tbl