FIELD: biochemistry, medicine, virology. SUBSTANCE: polypeptides of the formula (I): A1-Trp-Cys-A2-A3-Lys-Cys-A2-A3-Gly-A4-Cys-A2-A3-Cys-Arg-NH2 where: A1 - H, Lys, Arg; A2 - Tyr, Phe, Trp; A3 - Arg, Lys; A4 - Ala, Val, Leu, Ile, Ser, Met and two pairs of cysteine residues at positions 3 and 16 and at positions 7 and 12 can be linked by disulfide bridge -S-S-, or their salts. Polypeptides were synthesized by method of solid phase synthesis, closing disulfide bridges between 3 and 16 and 7 and 12 cysteine residues is carried out by chemical oxidation in the air. Pharmaceutical composition shows antiviral activity against human immunodeficiency virus and contains effective amount of polypeptide (I) or its salt as an active substance. EFFECT: improved method of synthesis. 5 cl, 3 dwg
