FIELD: organic chemistry. SUBSTANCE: product: pyrazole derivatives of the formula (I) where: L - group C=O or COR4, .... - optional bond; P - 0-1; R and R' - independently each of other - H, (C1-C6)-alkyl, free or substituted phenyl, benzyl, naphthyl, pyridyl; R2 - H, (C1-C6)-alkyl, -CH2COOH, (C1-C4)-alkoxy-COCH2, C(O)(A)t-Y; t = 1; A - NH; Y - phenyl substituted with CF3 and/or Hal; R4 - (C1-C6)-alkyl, -CH2COOH, (C1-C4)-alkoxy-COCH2; R3 - H or group of formulas (II) or (III) where: B - O or S; X - Hal; m = 0-2; n = 0-1; Q - NH, -N(C1-C6)-alkyl, S; R5 - group [CH(R6)]q(CH2)r-R where R6 - (C1-C6)-alkyl; q = 0-1; r = 0-2; R7 - H, (C1-C8)-alkyl, pentafluorophenyl, pyridyl, tetrahydronaphthyl, indolyl, quinolinyl, free or substituted phenyl or naphthyl, or group (Q)n-R5-2-tetrahydroisoquinolinyl, or their pharmaceutically acceptable salts. Synthesized compounds were used in chemical-pharmaceutical industry. EFFECT: improved method of synthesis. 8 cl
Authors
Dates
1997-03-27—Published
1991-07-16—Filed