METHOD OF INJECTION OF MEDICINAL AGENTS INTO BIOLOGIC TISSUE AND DEVICE FOR ITS REALIZATION (VARIANTS) Russian patent published in 1997 - IPC

FIELD: medicine, for surface injection of medicinal agents into biologic tissue to a high depth. SUBSTANCE: method of injection of medicinal agents into biologic tissue consists in spraying of medicinal agent in the form of an aerosol flame exposed to ultrasonic vibrations at a vibration frequency of 44 to 66 kHz and vibration amplitude action of audio-frequency ultrasound on biologic tissue at a vibration frequency of 26.5 kHz and vibration amplitude within 40 to 50 um, at an exposure of 5 to 10 s/sq.cm; a local heat-affected zone at temperature of 45 to 50 C is preliminarily produced above the biologic tissue surface up to the onset of developed sweating from it; then biologic tissue is abruptly chilled by an aerosol flame of medicinal agent down to a temperature of 20 to 25 C; and action by audio-frequency ultrasound is accomplished after spraying of medicine; besides; at the same time action by variable magnetic field is accomplished with a magnetic induction amplitude within 30 to 40 mT. The method is realized by means of devices, the first of which has a cylindrical bearing casing, whose bottom has a central hole with a vessel filled with a solution of medicinal agent and an acoustic unit installed in it; the acoustic unit includes an ultrasonic transducer and a radiator; the bearing casing accommodates a hemisphere with a central hole aligned with the casing central hole, the hemisphere base is fastened to the casing base through a hollow flexible toroidal element furnished with an air blower; installed in the central holes of the hemisphere and casing is the replaceable acoustic unit, whose radiator has a vibration frequency of 44 to 66 kHz; the plane of its working end is positioned between the planes of the ring heating element and temperature-sensitive element secured on the internal surface of the hemisphere; aligned drain holes are made in the bases of the hemisphere and casing for their closing with shutters linked with electromagnets; sources of variable magnetic field are installed on the external surface of the casing. The other device is furnished with an acoustic unit installed in the central hole of the bearing casing, on the centric fluoroplastic hemisphere; its radiator has a vibration frequency of 26.5 kHz, and the working end is made in the form of a convex hemisphere, whose surface is added with uniformly spaced hemispherical lugs; the casing carries also a ring heating element, temperature - sensitive element, electromagnets and variable magnetic field sources; the hemisphere and casing bases have aligned drain holes. EFFECT: injection of medical agents to a high depth in biologic tissue without disturbance of dermal integument. 4 cl, 5 dwg