FIELD: organic chemistry. SUBSTANCE: novel compounds namely 2- aminoimidazole and 2-aminothiazole hydrochloride of general formula (I): containing aryl substituent in position 4 and disulfide bridge in position 5 wherein X is alkylamino group, e.g. methylamino, and R1=R2 is hydrogen; X is methylamino group, and R1 is alkyl, e.g. methyl and R2 is hydrogen; X is methylamino group, and R1 is alkoxy, e. g. methoxy and R2 is hydrogen; X is methylamino, and R1 is ethoxy and R2 is hydrogen; X is methylamino, and R1 is halogen, e.g. chlorine and R2 is hydrogen; X is methylamino, and R1=R2 is alkoxy, e.g. methoxy; X is ethylamino, and R1 is alkoxy e.g. methoxy and R2 is hydrogen; X is sulfur, and R1 is alkoxy, e. g. methoxy and R2 is hydrogen; X is sulfur and R1=R2 is alkoxy, e. g. methoxy; X is sulfur, and R1 is halogen, e.g. fluorine and R2 is hydrogen, novel compounds have cytoxic and antitumor activity and show inhibitory effect to some enzymes. EFFECT: enhanced efficiency. 1 dwg, 4 tbl
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Authors
Dates
1997-04-10—Published
1995-07-31—Filed