FIELD: medicine.
SUBSTANCE: group of inventions refers to substances preventing malignant regeneration of mammal (including human) normal cells in malignant cells. Aaptos sp. sponge is used to produce an aaptamine analogue, namely 3-N-morpholinyl-9-demethyloxyaaptamine exhibiting ability to prevent mammal normal cell transformation in malignant cells. What is offered is use of 3-N-morpholinyl-9-demethyloxyaaptamine, and also its analogues 9-demethyloxyaaptamine, isoaaptamine, 3-phenethylamino-9-demethyl oxyaaptamine and 3-isopentyl amino-9-demethyloxyaaptamine as such agent. Besides, these substances are used for preparing pharmaceutical compositions preventing mammal normal cell transformation in malignant cells. 3-N-morpholinyl-9-demethyloxyaaptamine and its analogues have a cancer-preventive effect in the concentration nontoxic for normal cells.
EFFECT: reduced risk of toxic action on body after prolonged administration of the substances.
3 cl, 1 dwg, 10 tbl, 7 ex
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| CYTOTOXIC AND ANTIVIRAL ACTIVITY OF 3-ACYLOXYMETHYL-3-OXO-1-CYANO-2,3-SECO-2-NOR-TRITERPENOIDS | 2018 |
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