DERIVATIVES OF BENZANILIDE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION EXHIBITING ANTAGONISM TO 5-HT RECEPTORS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: N-[4-chloro-3-(4-methyl-1-piperazinyl)-phenyl] -2'-methyl-4'-(5-methyl-1,2,4-oxadiazole-3-yl)-1,1'-biphenyl-4-carboxamide, empirical formula is C₂₈H₂₈ClN₅O₂•0,5 H₂O•0,4 C₂H₆O. Value R_f = 0.56 by TLC method in system dichloromethane/ethanol/ammonia. Synthesized compounds were used in medicine for treatment and prophylaxis of depression and other disorders of central nervous system. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis. 18 cl