CYCLIC AMINE DERIVATIVES, OBTAINMENT METHODS, AND PHARMACEUTICAL COMPOSITIONS THEREOF Russian patent published in 2010 - IPC C07D211/34 C07D405/12 C07D405/04 A61K31/445 A61K31/4465 A61P25/24 

FIELD: chemistry.

SUBSTANCE: in novel compounds of the formula (I) R is radical selected out of i) , ii) , iii) , iv) , where R₇ is halogen, cyano, C_1-4alkyl, C_1-4alkoxy; p is integer within 0 to 3; R₁ is hydrogen, C_2-4alkenyl or C_1-4alkyl; R₂ is hydrogen or C_1-4alkyl; R₃ and R₄ are independently hydrogen or C_1-4alkyl; R₅ is: phenyl substituted with 1-3 groups selected independently out of trifluoromethyl, C_1-4alkyl, cyano or halogen; naphthyl substituted with 1-3 groups selected independently out of trifluoromethyl, C_1-4alkyl, cyano or halogen; benzofurane substituted with 1-3 groups selected independently out of C_1-4alkyl or halogen; R₆ is hydrogen or (CH₂)_qR₈; R₈ is hydrogen; m is zero or 1; n is 1; q is an integer within 1 to 4; r is 1 or 2; provided that if R₅ is phenyl substituted with 1-3 groups selected independently out of trifluoromethyl, C_1-4alkyl, cyano or halogen, then R is not radical i) ; and pharmaceutically acceptable salts or solvates thereof. The invention also refers to method (A) of compound obtainment, to compound application, to pharmaceutical composition, as well as to mammal treatment method.

EFFECT: obtainment of novel bioactive compounds with tachykinin receptor antagonist activity.

16 cl, 116 ex