BIODEGRADABLE ARGININE-CONTAINING POLYMERS Russian patent published in 2015 - IPC C08G73/02 A61K31/198 A61K47/30 A61K47/48 A61K31/155 

FIELD: biotechnology.

SUBSTANCE: invention relates to a biodegradable synthetic polymer, namely to the polymer of the general formula (I) , where ^NA has the structure: , A^N has the structure: , where n is an integer >2; Z is either absent or is an amino acid residue -NH-(CH₂)_i-CO-, where i - is an integer from 1 to 5; D represents a linear or branched alkyl C₁-C₅ or benzyl; B represents a residue of aliphatic diamine -NH-(CH₂)_k-NH-, where k is an integer from 2 to 6; X and Y can simultaneously have the following meanings: X=H-B, Y=H, or X=N_α-(D-OCO)-L-arginyl-Z-B, Y=N_α-(D-OCO)-L-arginyl-Z, or X=R¹-A^N-B, Y=^NA-R¹, where R¹ is carboxamide-alkyl of the type H₂NCO-CH₂- or H₂NCO-CH₂CH₂-. Such a polymer is capable of delivering the natural L-arginine into the tissues of human, animals, through biological membranes and can be used alone or in a combination with other active compounds.

EFFECT: invention enables to obtain the polymer soluble in water, which has no cytotoxicity and enhances the level of nitrogen oxide in the tissues of humans and animals.

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