FIELD: chemistry of peptides, biochemistry. SUBSTANCE: product: peptide derivatives of the formula: H(D)-Arg-Arg-Pro-C-Gly-E-Ser-(D)-Phe-X-Oic-Arg-OH where: E - Phe, Thia; C - Hyp, Pro; X - H, Cl that were synthesized by solid-phase synthesis using peptide synthezator and F-moc-method on p-benzylhydroxybenzylic alcohol-base resin esterified with F-moc-Arg(Mtz)OH. Synthesized compounds show low toxicity: IC50 = 1.4 x 10-8 M. Synthesized compounds show bradykinin-antagonistic action. EFFECT: improved method of synthesis. 2 cl, 1 tbl
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