FIELD: biochemistry. SUBSTANCE: described are new protected amino acid derivatives of general formula I: Nα wherein 
is hydrogen atom, and R1 is hydroxymethyl, 1- hydroxyethyl, 4-hydroxybenzyl, imidazolyl-2-methyl, benzyloxymethyl, 1-benzyloxyethyl, 4-benzyloxybenzyl, benzyloxycarbonylmethyl, 2-(benzyloxycarbonyl)ethyl, S- benzylthiomethyl, S-(diphenylmethyl)thiomethyl, 4- (benzyloxycarbamido)butyl, 3-quanidinopropyl, 3-R2- toluenesulfonyl)guanidinopropyl, 3-(NG- nitro)guanidinopropyl, 3-NG-(4-methoxy-2,3,6- trimethylbenzenesulfonyl guanidinopropyl, N-(4,4- dimethoxybenzhydryl)carboxamidomethyl, 2-[N-(4,4- dimethoxybenzhydryl)carboxamido]ethyl, S-tert- butyldithiomethyl, 4-(2- nitrophenylsulfonyl)ethyoxycarbamido)-butyl, propyl, butyl, ethyl, 3-(benzyloxycarbamido) propyl, or 3-(tert- butoxycarbamido)propyl. Said derivatives are useful for synthesis of peptides. Also described is method of preparation thereof. EFFECT: more efficient preparation method. 7 cl, 7 ex, 2 tbl
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