METHOD OF SYNTHESIS OF CLAVULANIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND ETHERS, CLAVULANIC ACID SALT WITH AMINE Russian patent published in 1997 - IPC

FIELD: chemical technology. SUBSTANCE: invention proposes method of synthesis and/or purification of clavulanic acid or its pharmaceutically acceptable salts or ethers. Method involves contact of crude clavulanic acid or its labile derivative in organic solvent with amine of the formula (II): where: R^I - group of the formula ; R², R³, R⁴, R⁵ - hydrogen or C₁-C₆-alkyl; m = 0-5. Invention relates to also isolation of clavulanic salt formed with amine, conversion of salt to clavulanic acid or its pharmaceutically acceptable salt or ether. Invention proposes also clavulanic acid salt and amine of the formula (II) . EFFECT: improved method of synthesis. 40 cl