METHOD OF PREPARING CLAVULANIC ACID SALT Russian patent published in 1999 - IPC

Abstract RU 2140418 C1

FIELD: chemical industry. SUBSTANCE: clavulanic acid in solution of completely or partially water immiscible organic solvent is contacted with precursor salt compound in high turbulence and/or shear tension so as to form clavulanic acid salt solution in aqueous phase. Organic solvent and aqueous phase are physically separated at separation stage followed by treatment stage where said clavulanic acid salt is isolated from solution as solid substance. EFFECT: reduced hydrolytic destruction of the desired product. 27 cl, 3 dwg

Similar patents RU2140418C1

Title	Year	Author	Number
METHOD OF PREPARING CLAVULANIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS	1995	Majkl Allen Kuk[Gb] Robert Bennett Uilkins[Gb]	RU2088586C1
METHOD OF SYNTHESIS OF CLAVULANIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND ETHERS, CLAVULANIC ACID SALT WITH AMINE	1995	Majkl Allen Kuk[Gb] Robert Bennett Uilkins[Gb]	RU2081121C1
METHOD OF PREPARING AND/OR PURIFYING CLAVULANIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS THEREOF CLAVULANIC ACID SALT WITH AMINO ACID	1993	Majkl Allen Kuk[Gb] Robert Bennett Uilkins[Gb]	RU2105768C1
6-(SUBSTITUTED METHYLENE)PENEMS, METHOD OF PREPARING THEREOF, INTERMEDIATE PRODUCTS, AND PHARMACEUTICAL COMPOSITION	1993	Najdzhel Dzhon Perrimen Brum Frehnk Peter Kharrington	RU2133750C1
METHOD OF EPOXIDATION OF PROCHIRAL OLEFIN	1995	Bell Dehvid Finnej Frantsiska Attrill Robin Patrik Miller Dehvid Terner Dzhillian	RU2204562C2
METHOD OF TREATMENT OF STATE WHERE 5HT-LIKE AGONIST, DERIVATIVE OF TETRAHYDROCARBAZOLE IS REQUIRED, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY OF AGONIST OF 5HT-LIKE RECEPTORS	1992	Frehnsis Dehvid King Larami Mehri Gehster Al'Berto Dzhulio Kaumann Rodni Kristofer Jang	RU2137474C1
METHOD OF SYNTHESIS OF 4-(4'-FLUOROPHENYL)-3-HYDROXYMETHYL-PIPERIDINES AND METHOD OF SYNTHESIS OF 4-(4'-FLUOROPHENYL)-3-(3',4'-METHYLENEDIHYDROXYPHENOXYMETHYL)-PIPERIDINE	1994	Sidnej Ehdvard Kehllender	RU2141477C1
CONDENSED INDOLE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY OF 5-$$$-RECEPTOR ANTAGONIST	1993	Lehrami Mehri Gaster[Gb] Pol Adrian Vajman[Gb]	RU2104279C1
SUBSTITUTED THIAZOLIDINEDIONE AND METHOD OF PREPARING THEREOF	1993	Kolin Ripli Pul Robin Shervud Roman Mal'Kol'M Dehvid Brajvell Alan Uil'Jam Tremper	RU2128179C1
METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS	1993	Mokhamed Kejr Mokallalati Lendon Norvud Pridzhen Sjuzn Shilkreht Dzhozef Vejnstok	RU2128174C1

RU 2 140 418 C1

Authors

Majkl Alehn Kuk

Dzheffri Kliv Vebb

Dates

1999-10-27—Published

1995-01-31—Filed