FIELD: pharmacy. SUBSTANCE: method involves: contact of crude clavulanic acid or its labile derivative with tert.-octylamine in organic solvent; isolation of clavulanic acid salt formed with tert.-octylamine; conversion of this salt to clavulanic acid or its pharmaceutically acceptable salt or ester. Additional effect of method: simultaneous purification of clavulanic acid or its derivatives. EFFECT: improved method of preparing and purification. 37 cl, 1 tbl
| Title |
Year |
Author |
Number |
| METHOD OF PREPARING AND/OR PURIFYING CLAVULANIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS THEREOF CLAVULANIC ACID SALT WITH AMINO ACID |
1993 |
- Majkl Allen Kuk[Gb]
- Robert Bennett Uilkins[Gb]
|
RU2105768C1 |
| METHOD OF SYNTHESIS OF CLAVULANIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND ETHERS, CLAVULANIC ACID SALT WITH AMINE |
1995 |
- Majkl Allen Kuk[Gb]
- Robert Bennett Uilkins[Gb]
|
RU2081121C1 |
| METHOD OF PREPARING CLAVULANIC ACID SALT |
1995 |
- Majkl Alehn Kuk
- Dzheffri Kliv Vebb
|
RU2140418C1 |
| CONDENSED INDOLE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY OF 5-$$$-RECEPTOR ANTAGONIST |
1993 |
- Lehrami Mehri Gaster[Gb]
- Pol Adrian Vajman[Gb]
|
RU2104279C1 |
| 6-(SUBSTITUTED METHYLENE)PENEMS, METHOD OF PREPARING THEREOF, INTERMEDIATE PRODUCTS, AND PHARMACEUTICAL COMPOSITION |
1993 |
- Najdzhel Dzhon Perrimen Brum
- Frehnk Peter Kharrington
|
RU2133750C1 |
| METHOD OF TREATMENT OF STATE WHERE 5HT-LIKE AGONIST, DERIVATIVE OF TETRAHYDROCARBAZOLE IS REQUIRED, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY OF AGONIST OF 5HT-LIKE RECEPTORS |
1992 |
- Frehnsis Dehvid King
- Larami Mehri Gehster
- Al'Berto Dzhulio Kaumann
- Rodni Kristofer Jang
|
RU2137474C1 |
| METHOD OF CLAVULANIC ACID SALT PREPARING |
1996 |
|
RU2179171C2 |
| METHOD OF SYNTHESIS AND/OR PURIFICATION OF CLAVULANIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR ESTER AND METHOD OF ITS SEPARATION FROM IMPURITY OF CLAVAM-2-CARBOXYLIC ACID CONTAINING IN FILTERED OFF FERMENTATION BROTH |
1996 |
|
RU2166506C2 |
| METHOD FOR STEREOSPECIFIC HYDROLYSIS OF PIPERIDINEDIONE DERIVATIVES |
1993 |
- Alan Dehvid Kurzons[Gb]
- Loson Uill'Jam Pauehll[Gb]
- Alan Martin Ki[Gb]
|
RU2108393C1 |
| HETEROCYCLIC COMPOUND OR ITS TAUTOMERIC FORM AND/OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PHARMACEUTICALLY ACCEPTABLE SOLVATE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD GLUCOSE LEVEL, METHOD OF TREATMENT AND/OR PROPHYLAXIS OF HYPOGLYCEMIC PATIENTS |
1993 |
- Dehvid Khej
- Dzhon Tomas Sajm
|
RU2134686C1 |
