FIELD: organic chemistry and chemical technology. SUBSTANCE: invention relates to new clavulanic acid diamine salts of the formulas (IIa, IIb) where R1 and R2 each means (C1-C4)-alkyl group or they bound each with other to form piperidino-group or morpholino-group; R3 and R4 each means (C1-C4)-alkyl group or they bound each with other to form piperidino-group; X means hydrogen atom or hydroxy-group; m and n each independently = 0-5. Compounds of the formula (IIa, IIb) are synthesized by interaction of clavulanic acid with diamine of the formula (III) in an organic solvent. Invention proposes a method of purification of clavulanic acid also. EFFECT: improved and simplified method of synthesis. 12 cl, 2 tbl, 8 ex
Authors
Dates
1999-08-27—Published
1994-03-22—Filed