DIHYDRONAPHTHOPYRANE DERIVATIVES OR THEIR SALTS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION INHIBITING CELL PROLIFERATION Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: pharmaceutical compounds of the formula where: n = 0, 1 or 2 and R¹ is bound at any of positions 7, 8, 9 or 10 and each R¹ means halide, carboxy, trifluoromethyl, hydroxy, C_1-4-alkyl, C_1-4-alkoxy, C_1-4-thioalkyl, hydroxy-C_1-4-alkyl, hydroxy-C_1-4-alkoxy, nitrogen-containing heterocycle, nitro, trifluoromethoxy, -COOR⁵ where: R⁵ - ester group, -COR⁶,-CONR⁶R⁷ or -NR⁶R⁷ where R⁶ and R⁷ each means hydrogen or C_1-4-alkyl; R² - phenyl, naphthyl or heteroaryl taken from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl being the indicated phenyl, naphthyl and heteroaryl group can be optionally substituted or R² - furanyl optionally substituted with C_1-4-alkyl; R³ - nitrile, carboxy, -COOR⁸ where R⁸ - ester group or -CONR⁹R¹⁰ where R⁹ and R¹⁰ each means hydrogen or C_1-4-alkyl; and R⁴ - -NR¹¹R¹²,-NR¹¹COR¹²,-N(COR¹¹)₂ or -N=CHO-CH₂R¹¹ where R¹¹ and R¹² each means hydrogen or C_1-4-alkyl optionally substituted with carboxy-group, -N=CH-NR¹³R¹⁴ where R¹³ - hydrogen or C_1-4-alkyl and R¹⁴ - C_1-4-alkyl, optionally substituted phenyl or optionally substituted heteroaryl where: X - C_2-4-alkylene or -NHSO₂R¹⁵ where R¹⁵ - C_1-4-alkyl, trifluoromethyl or optionally substituted phenyl, and their salts. EFFECT: improved method of synthesis. 8 cl