FIELD: medicine. SUBSTANCE: method involves removing fat and connective tissue from milt of fish, homogenization, filtration, centrifugation, precipitate washing with Ringer solution, ultrasonic oscillation treatment. The obtained solution is purified by ion-exchange chromatography, treatment with acetic anhydride at ratio protamine : acetic anhydride = (1:100)-(1:300) followed by isolation of the end product by chromatography. The obtained product is used for heparin inactivation. EFFECT: increased antiheparinic activity. 1 dwg
| Title | Year | Author | Number |
|---|---|---|---|
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| 4-AZIDONAPHTHALENE-1-SULFONYLCHLORIDE AS SEMIPRODUCT FOR SYNTHESIS OF (1′R,5′R) -3′-AZA-1′ -(2-AMINO-1,6-DIHYDRO-6-OXOPURINYL-9)-- 3′-DEOXY-3′- (4-AZIDONAPHTHALENE-1-SULFAMIDO) HEXOPYRANOSYL-- 6′-TRIPHOSPHATE TRILITHIUM SALT AS SPECIFIC PHOTOACTIVATED IRREVERSIBLE RNA-POLYMERASE INHIBITOR | 1991 |
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SU1138824A1 |
