FIELD: organic chemistry. SUBSTANCE: products: derivatives of bis-benzo- or benzopyrido-cycloheptapiperidine, piperidylidene and piperazine of the formula (I) where: Z - group CH2-Y where Y - CH2, -O- or -S-, -CH= CH-, -O- or the bond; L - N-atom or group N+-O-; X - nitrogen atom or group CH; T - nitrogen atom ; R2 - hydrogen or halogen --- presence or absence of the bond. Reagent 1: compound of the formula (II) . Reagent 2: compound of the formula (III) . Reaction conditions: in medium of inert organic solvent in the presence of the base. Synthesized compounds were used in medicine as antagonists of factor activating platelets and histamine. EFFECT: improved method of synthesis. 2 cl, 6 tbl
Authors
Dates
1997-08-10—Published
1991-06-21—Filed