FIELD: organic chemistry. SUBSTANCE: product: WS7622A disulfates or their pharmaceutically acceptable salts: WS7622A disulfate disodium salt, empirical formula C47H61N19S2Na26H20, molecular mass FAB-MS M/Z 1188(M+ Na)+, colorless crystals, m. p. is 257-263 C (at decomposition). Dipotassium salt of WS7622A 1b- sulfate, empirical formula is C47H61N9O19S2K2•6H20,, molecular mass FAB-MS M/Z 1236 (M + K)+, amorphous powder, m. p. is 230-237 C (at decomposition). Both salts are good soluble in water and methanol, insoluble in chloroform, n-hexane. Pharmaceutical composition has effective amount of WS7622A as potassium or sodium salt as an active component. Proposed compound is used in medicine since it inhibits human leukocyte elastase activity. EFFECT: enhanced effectiveness of composition. 4 cl, 5 tbl, 5 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCTION OF COMPOUNDS WS 7622 A, B, C AND/OR D-INHIBITORS OF HUMAN LEUCOCYTEELASTASE OR THEIR PHARMACEUTICALLY AVAILABLE SALTS | 1990 |
|
RU2051174C1 |
| PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1992 |
|
RU2043365C1 |
| METHOD OF SYNTHESIS OF PYRAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2021990C1 |
| PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF DISEASE TREATMENT INTERMEDIARY AGENT OF THAT IS TACHIKININ | 1991 |
|
RU2073683C1 |
| METHOD OF SYNTHESIS OF COMPOUND "WS7622A" DERIVATIVES | 1990 |
|
RU2021280C1 |
| DERIVATIVES OF INDOLYLPYPERIDINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1991 |
|
RU2039056C1 |
| CEPHEM COMPOUND OR ITS PHARMACEUTICALLY ACCEPTABLE SALT | 1992 |
|
RU2024530C1 |
| AMIDES OF ACIDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2208608C2 |
| ANTIBIOTIC COMPOSITION | 1988 |
|
RU2029549C1 |
| CEPHEM COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1992 |
|
RU2081874C1 |
