PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF DISEASE TREATMENT INTERMEDIARY AGENT OF THAT IS TACHIKININ Russian patent published in 1997 - IPC

FIELD: peptides. SUBSTANCE: product: derivatives of peptides of the general formula (I):

where: R¹ - free phenyl or phenyl substituted with halogen or lower alkoxy; benzofuryl; pyridyl or indolyl; R² - hydrogen or lower alkyl; R³ - lower unsubstituted alkyl or alkyl substituted 1-3 times with halogen; amino; lower alkanesulfonylamino; carboxy (lower) alkoxy; unsubstituted or esterified halogen, lower alkoxy, nitro; R⁴ - lower alkyl; R⁵ - phenyl (lower) alkyl; R⁷ - hydrogen; lower alkyl; halogen; A - hydroxy- or didehydroxyproline; Y - bond, lower alkylene, lower alkenylene or their pharmaceutically acceptable salts. Reagent 1: HAN(R²)CH(CH₂C₆H₅R³R⁷)CONR⁴R⁵. Reagent 2: R¹-Y-COOH. In the synthesized product ester group R³ is removed or nitro-group in radical R³ is reduced. Pharmaceutical composition has pharmaceutically acceptable carrier and compound of the formula (I) as an active agent at amount 0.1-1000 mg as a single dose. Method of treatment of diseases intermediary agent of that is tachikinin involves prescription to patient the compound of the formula (I) at dose 0.1-1000 mg/day. EFFECT: improved method of synthesis, enhanced effectiveness of treatment. 9 tbl