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2 088 228

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C1

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IPC

(21) (22)

Application

95111205/14, 1995-07-07

(22)

Actual filing date

1995-07-07

(45)

Published

1997-08-27

(72)

Inventor

Nikol'Skaja T.A.Margolin A.L.Shljapintokh V.Ja.Burlakova E.B.Al'Perovich M.A.Slonimskij Ju.L.Ushomirskij M.N.

(73)

Holder

Institut Biokhimicheskoj Fiziki RanAktsionernoe Obshchestvo I Proektnyj Institut Khimiko-Fotograficheskoj Promyshlennosti"

PHOTOINITIATING AGENT OF MALIGNANT CELLS Russian patent published in 1997 - IPC

Abstract RU 2088228 C1

FIELD: organic chemistry. SUBSTANCE: product: thiodicarbocyanine dye of the formula: where: X - (X = CH3C6H4SO-3

). The proposed dye polymethin accumulates selectively in malignant cells, inhibits effectively solid tumor growth in mice and kills malignant cells in vitro. At lower irradiation doses its effectiveness is 1.5-4.0-fold exceeds that of the known photoinitiating agent cryptocyanine. Agent can be used in oncology for photodynamic cancer therapy. EFFECT: enhanced effectiveness of agent. 1 dwg, 2 tbl

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RU 2 088 228 C1

Authors

Nikol'Skaja T.A.

Margolin A.L.

Shljapintokh V.Ja.

Burlakova E.B.

Al'Perovich M.A.

Slonimskij Ju.L.

Ushomirskij M.N.

Dates

1997-08-27—Published

1995-07-07—Filed

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