WATER-SOLUBLE BACTERICIDAL COMPOSITION AND A METHOD OF ITS PREPARING Russian patent published in 1997 - IPC

FIELD: pharmacy. SUBSTANCE: composition has highly dispersed metallic silver stabilized with protective high-molecular compound. Composition has the following components, mas. p. p.: poly-N-vinylpyrrolidone-2 of molecular mass (8 x 10³)-(1.63 x 10⁶) Da 1, and highly dispersed metallic silver, 0.01-2.33. Method of preparing these compositions involves interaction of silver nitrate with poly-N-vinylpyrrolidone-2 aqueous-spirituous solution at the following component concentrations, wt.-%: poly-N-vinylpyrrolidone-2, 0.065-11.00; silver nitrate, 0.025-29.73; ethyl alcohol, 5.0-38.6; and water, the balance, up to 100. Interaction is carried out in darkness at 65-75 C in atmosphere of inert gas. Method ensures to decrease process time by 20-280-fold, silver loss by 20-100-fold, toxicity of the preparation by 4-6-fold as compared with the known preparations. Composition is stable at room temperature without changes and disperses after water addition. Composition can be used in medicine and veterinary science. EFFECT: enhanced effectiveness, decreased toxicity. 2 cl, 1 tbl