FIELD: organic chemistry. SUBSTANCE: product: derivatives of N-alkylenepiperidine of the formula: Ar-X-
-Z where: Ar - phenyl, pyridyl, 1-methylimidazolyl-2; 
- 3,4-dichlorophenyl, naphthyl; X - oxygen, sulfur, -NH-, -N(CH3)-, -N-(COCH3); R - hydrogen, methyl; Z - 2,4-dichlorophenyl, 2,4-dimethoxyphenyl; 3-chlorophenyl, 3-isopropoxyphenyl, 4-fluoronaphth-1-yl or their hydrochlorides, dihydrochlorides or their quaternary ammonium salts formed by piperidine nitrogen. Reagent 1: mesylate of the formula 
-C(O)-Z. Reagent 2: secondary amine of the formula Ar-X-
-H. Synthesized compounds were used in medicine as an antagonistic agents with respect to neurokinin receptors. EFFECT: improved method of synthesis. 8 cl, 4 tbl
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Year |
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Number |
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|
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