FIELD: organic chemistry. SUBSTANCE: product: (-)-N-methyl-N-[4-(phenyl-4-acetaminopiperidine-1-yl)- -2-(3,4-dichlorophenyl)-butyl] -benzamide and its pharmaceutically acceptable salts. Reagent 1: (+)-HO-
. Reagent 2: functional derivative of benzoic acid. Product of their interaction is treated with dihydropyrane. The obtained compound is subjected for interaction with dimethylsulfate and after removal of oxygen-protective group is treated with derivative of benzosulfoacid and 4-acetylamino-4-phenylpiperidine successively. The synthesized compounds were used in medicine as antagonists of neurokinin receptors. EFFECT: improved method of synthesis. 7 cl
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