POLYCYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS, METHOD OF SYNTHESIS OF POLYCYCLIC AMINE-CONTAINING COMPOUNDS, CYCLIC AMINE-CONTAINING COMPOUNDS OR THEIR SALTS, THEIR OPTICALLY PURE ISOMERS AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO NEUROKININ RECEPTORS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: products: polycyclic amine-containing compounds of the formula (I) where: y - ; Ar - phenyl; x = 0 or 1; X - hydrogen, hydroxyl, acetoxy or acylamino-group; m = 2 or 3; Ar′ - phenyl or naphthyl; n = 0, 1, 2 or 3; p = 1 or 2 at condition that when p = 2 then n = 1 and Q - two oxygen atoms; Q - oxygen or two hydrogen atoms; T - -C(O)- or -CH₂-; q = 0 or 1; Z - phenyl. Reagent 1: compound of the formula (II) . Reagent 2: HOC(O)-(CH₂)_q or Hal-(CH₂)_q+1-Z where Hal - halogen; E - hydroxyl or O - protected group. From the synthesized compound (III) the protected group is split and treated with CH₃SO₂Cl and the secondary amine of the formula (IV) . Synthesized compounds were used in medicine as antagonists of neurokinin receptors. EFFECT: improved method of synthesis. 13 cl, 8 tbl