N-PHENYL-2-CYANO-3-HYDROXYCROTONIC ACID AMIDE, METHOD OF ITS SYNTHESIS AND DRUG SHOWING ANTIINFLAMMATORY ACTIVITY WITH RESPECT TO RHEUMATIC DISEASE, AUTOIMMUNE DISEASE OR REJECTION RESPONSE OF RECIPIENT TRANSPLANTABLE ORGAN Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: N-phenyl-2-cyano-3-hydroxycrotonic acid amide of the formula (I) given in description where: R¹ - hydrogen; R³ - lower alkyl; R² - halogen, nitro, cyano, trifluoromethyl. Synthesis: interaction of reagent 2 with reagent 3 of formulas given in description where Z means halogen atom followed by treatment of the synthesized compound with a base. Drug showing antiinflammatory activity has an active substance (I) and additions, shows immunomodulating effect and can be used in pharmaceutical industry. EFFECT: improved method of synthesis. 5 cl, 4 tbl