7-OXABICYCLOHEPTYL-SUBSTITUTED HETEROCYCLIC AMIDES OR STEREOISOMERS THEREOF AS THROMBOXANE RECEPTOR ANTAGONISTS Russian patent published in 1994 - IPC

Abstract RU 2015980 C1

FIELD: medicine; used as thromboxane receptor antagonists. SUBSTANCE: the product: 7-oxabicycloheptyl-substituted heterocyclic amides of the formula 1 or stereoisomers thereof wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4; Z is CH2-CH2 or -CH=CH-, provided that when Z is -CH=CH-, n is not 0; R is carboxyl, an alkaline metal salt thereof, carboxy-(C1-C8)-alkyl, CONHSO2(C1-C8)-alkyl, CONHSO2-phenyl, CONHSO2-benzyl or CH2-5-tetrazolyl; X is 0 or $ or NH; R1-C1-C16-alkyl, optionally substituted by C3-C8-cycloalkyl or phenyl which may contain a halogen atom; C3-C8-cycloalkyl or phenyl which may be substituted by halogen; R2 is H or C1-C8-alkyl or R1 end R2 taken together with the adjacent nitrogen atom form a 5 to 8 member ring. The structure of the compound of the formula 1. EFFECT: improved properties of the title compounds. 2 tbl, 1 dwg

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RU 2 015 980 C1

Authors

Filip M.Sher[Us]

Filip D.Stejn[Us]

Dehvid Flojd[Us]

Stiven E.Kholl[Us]

Dates

1994-07-15Published

1991-09-30Filed