RACEMIC OR OPTICALLY ACTIVE PERHYDRO-1H-PYRIDO-[1,2-A]-PYRAZINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND METHOD OF THEIR SYNTHESIS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: products: perhydro-1H-pyrido- -[1,2-a] -pyrazines of the formula (I) given in description or their salts where: L and X were taken separately where: X - H; L - R(CH₂)_mCO or L and X taken together form groups of formulas (I-VII) given in description where: R - C₃-C₇-cycloalkyl, phenyl or norbornyl; R¹, R² and R³ - H or CH₃; Y - O or S; y¹ - CH₂ or S; y² and y³ - H or y² and y³ taken together mean (CH₂)_q; Z - H or Cl; m = 0, 1, 2 or 3; n = 1, 2, 3 or 4; p = 1 or 2; q = 3, 4 or 5; --- means bond or its absence. Reagent 1: compound of the formula (VIII) given in description where y and n as given above; D - nucleophilic splitting off group. Reagent 2: L-NH(X) in the case when L and X form together with nitrogen atom piperidine derivative. Reaction conditions: in medium of organic solvent. Synthesized compounds were used in psychiatry. EFFECT: improved method of synthesis. 39 cl, 3 tbl