2,7-SUBSTITUTED DERIVATIVES OF OCTAHYDRO-1H-[1,2-A]-PYRAZINE, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF BINDING DOPAMINE WITH DOPAMINE D RECEPTOR Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of substituted pyrazine of the formula (I) where Ar is phenyl, naphthyl, indolyl, indolonyl, benzimidazolyl, quinolyl optionally substituted with one-three substitutes taken among the group described in the invention claim; Ar¹ means phenyl, pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl optionally substituted with one-two substituted taken among the group described in the invention claim also, or their pharmaceutically acceptable salts. Invention relates to also the pharmaceutical composition inhibiting the process of dopamine binding with dopamine D₄, receptors and method of inhibition of the process of dopamine binding with dopamine D₄ receptors based on the compounds described. EFFECT: new compounds indicated above, valuable pharmacological properties. 31 cl, 2 tbl, 57 ex