IMIDAZOPYRIDINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO HISTAMINE H Russian patent published in 1998 - IPC

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention describes derivatives of imidazopyridine of the general formula (I): where X is CH or N; Z means -CH=CH or S; A means -CH₂CH₂, CH=CH, CH(OH)-CH₂ or CO-CH₂; B means directed bond or -CH₂-,-CH(CH₃)₂- or when Z means CH=CH. B can form cyclopentane ring fused with the bound benzene ring; Y completes the condensed benzo- or thienyl ring that is substituted optionally with haloid- or C₁-C₄-alkyl; n = 0, 1 or 2 and m = 0 or 1. Synthesized compounds are antagonists of both ТАФ and histamine H₁, and can be used for treatment of patients with allergic inflammatory diseases (allergic rhinitis). Invention describes also a method of synthesis of derivatives of imidazopyridine of the formula (I) and pharmaceutical composition based on thereof. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 15 cl, 3 tbl