SOLID MEDICINAL FORMULA FOR ORAL ADMINISTRATION Russian patent published in 1997 - IPC

FIELD: medicine, gastroenterology, pharmacy. SUBSTANCE: solid medicinal formula oral administration involves nucleus consisting of omeprazole or its mixture with pharmaceutically acceptable alkaline agent, or a mixture of omeprazole alkaline salt with pharmaceutically acceptable alkaline agent. Nucleus is covered with at least one auxiliary envelope made of water-soluble and rapidly suspended in water. Enteric-soluble coating is covered on this envelope. Preferably, auxiliary envelope consists of one or more compounds taken from the group involving magnesium oxide, magnesium hydroxide and composition compounds of the formulas: Al₂O₃•6MgO•CO₂•12H₂O or MgO•H₂O₃•2SiO₂•nH₂O where: n - fractional number less 2, more preferably consisting of hydroxypropylcellulose, hydroxymethylcellulose or polyvinylpyrrolidone. In part, nucleus has a mixture of omeprazole and alkaline buffer compound providing micromedium pH value 7-12 around omeprazole. Alkaline agent is one or some compounds taken from the group involving aluminium oxide, hydroxide, aluminium, calcium, sodium or potassium carbonate, phosphate or citrate and composition compounds of the formulas Al₂O₃•6MgO•CO₂•12H₂O or MgO•Al₂O₃•2SiO₂•nH₂O where: n - fractional number less 2. Preferably - sodium, potassium, magnesium, calcium or ammonium salt of omeprazole. Enteric-soluble coating consists of the compound taken from the group involving hydroxypropylmethylcellulose phthalate, cellulose acetate phthalate, copolymer of methacrylic acid with methylmethacrylate and polyvinylpyrrolidone (preferably). Auxiliary envelope can contain pH-buffering alkaline compounds at humidity 1.5%, not above. The proposed medicinal formula is used for gastric secretion regulation and gastroenteric cytoprotective effect providing. EFFECT: enhanced effectiveness of composition. 10 cl, 8 tbl