DERIVATIVES OF BENZIMIDAZOLE AND METHOD PRODUCTION THEREOF Russian patent published in 1996 - IPC

FIELD: medicine. SUBSTANCE: desired product has common formula where X represents -S-, -SO; R¹-R⁴ which may be the same or different are hydrogen, alkyl having 1-8 (preferably 1-6) carbon atoms, alkoxy having 1-8 (preferably 1-6) carbon atoms; alkoxyalkoxy having 1-3 carbon atoms in each alkyl part. D in said formula represents ; R⁵ represents where substituent of phenyl group is in meta- or in para-position ; R⁶ represents hydrogen, alkyl having 1-8 (preferably 1-6) carbon atoms, R⁸ represents hydrogen, alkyl having 1-8 (preferably 1-6) carbon atoms, R⁷ represents alkoxy having 1-7 carbon atoms; A represents linear or branched alkylene having cycloalkylene group; Z₁ is ; Z₂ is ; R^∂,R^b,R^d and R^q are the same or different ; R^e is hydrogen, alkyl, benzyl; m is integer 0-8; p is 1-4; q is 1-4; r is 0-8; t is 0 or 1; v is 0 or 1. If said group D comprises phosphorous-containing group then it may be as mono-, di-, tri- or tetraionic salt. Compound having common formula where где R¹-R⁸ and X are as mentioned above and Z is halide (e. g. chlorine) is used as reagent 1. Compound R⁵-CO2M; having formulae where R5b