FIELD: organic chemistry. SUBSTANCE: product: 5-fluoro-2- -{[(4-cyclopropylmethoxy-2-pyridinyl)methyl] sulfinyl}-1H-benz- -imidazole or its physiologically acceptable salts, for example, sodium or magnesium, empirical formula is C17H16FN2O2S,, yield is 69%. Reagent 1: 5-fluoro-2-{[(4-cyclopropylmethoxy-2-pyridinyl)methyl] thio}-1H-benzimidazole. Reaction condition: in the presence of NaHCO3 an aqueous solution. Synthesized compound is used in medicine as therapeutic agent for prophylaxis and treatment of peptic ulcer. EFFECT: improved method of synthesis. 9 cl, 1 tbl
| Title |
Year |
Author |
Number |
| 4-FLUORO-2-{[ (4-METHOXY- 2-PYRIDINYL)METHYL]SULFINYL} -1H-BENZI- MIDAZOLE OR ITS PHYSIOLOGICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, AND PHARMACEUTICAL COMPOSITION OF 4-FLUORO -2-MERCAPTO-1H- BENZIMIDAZOLE AND 4-FLUORO -2-{[(4- METHOXY-2-PYRIDINYL) METHYL]THIO}-1H -BENZIMIDAZOLE |
1991 |
- Arne Ehlof Brehndstrem[Se]
- Per Lennart Lindberg[Se]
- Gunnel' Ehlisabet Sjunden[Se]
|
RU2042673C1 |
| 5-CHLORO-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL)- 1H-BENZIMIDAZOLE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION AND 5-CHLORO-2-[(3,4-DIMETHOXY-2- PYRIDINYL)METHYL)THIO]-1H-BENZIMIDAZOLE |
1989 |
- Arne Uljuf Brendstrem[Se]
- Per Lennart Lindberg[Se]
- Karl Ingemar Starke[Se]
- Gunnel' Ehlisabet Sjunden[Se]
|
RU2070199C1 |
| DERIVATIVES OF BENZIMIDAZOLE AND METHOD PRODUCTION THEREOF |
1987 |
- Tomas Ber'E Al'Minger[Se]
- Rol'F Aksel' Bergman[Se]
- Khans Bungord[Dk]
- Per Lennart Lindberg[Se]
- Gunnel Ehlizabet Sunden[Se]
|
RU2062778C1 |
| OPTICALLY PURE Na, Mg, Li, K OR Ca SALTS OF (-)-5-METHOXY-2-[[(4- -METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZ-IMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON SAID AND INTERMEDIATE COMPOUND |
1994 |
- Per Lennart Lindberg
- Sverker Von Unge
|
RU2137766C1 |
| ALKOXY-SUBSTITUTED BENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL PREPARATIONS COMPRISING THEREOF AND METHOD FOR THEIR USING |
2000 |
- Uittl Robert R.
- Sanchilio Frederik D.
- Stouehll Grehjson Uoker
- Dzhenkins Duglas Dzhon
- Uittol Linda
- Mejer Glenn Alan
- Fontana Stiven A.
|
RU2263673C2 |
| SOLID MEDICINAL FORMULA FOR ORAL ADMINISTRATION |
1992 |
- Kurt Ingmar Levgren[Se]
- Oke Gunnar Pilbrant[Se]
- Mitsuru Jasumura[Jp]
- Satosi Morigaki[Jp]
- Minoru Oda[Jp]
- Naokhiro Okhisi[Jp]
|
RU2095054C1 |
| DERIVATIVES OF BENZONITRILE OR THEIR RACEMATES OR PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTIARRHYTHMIC ACTION, AND COMPOSITION FOR CARDIAC ARRHYTHMIA TREATMENT |
1989 |
- Knut Olle Seved Al'Mgren[Se]
- Bernt Geran Duke Duker[Se]
- Krister Gert Strandlund[Se]
|
RU2024503C1 |
| SOLID MEDICINAL FORM OF THE PROLONGED ACTION FOR CARDIOVASCULAR DISEASE TREATMENT |
1991 |
- Ulf Ehrik Iensson[Se]
- Ien Al'Bert S'Egren[Se]
|
RU2072840C1 |
| DERIVATIVES OF 5-PYRROLYL-2-PYRIDYLMETHYLSULFONYLBENZIMIDAZOLE OR THEIR SALTS AND A METHOD OF THEIR SYNTHESIS |
1995 |
- Su Ung Kim[Kr]
- Dong En Kim[Kr]
- Gi Ju Chung[Kr]
- Sung Kol Khong[Kr]
- Sung Jun Park[Kr]
- Sang Khoon Nam[Kr]
- Eng Suk Li[Kr]
|
RU2100358C1 |
| METHOD FOR PRODUCTION OF OMEPRAZOLE |
1991 |
- Arne Ehlof Brendstrem[Se]
|
RU2061693C1 |
