FIELD: organic chemistry. SUBSTANCE: product: 4-fluoro-2 -{[(4-methoxy-2- pyridinyl)methyl] sulfinyl} -1H-benzimidazole (I), empirical formula is C14H15FN3O2S, yield is 89% or its physiologically acceptable salt, intermediate 4-fluoro -2-mercapto-1H- benzimidazole, empirical formula is C7H5FN2S and 4-fluoro -2-{[(4- methoxy-2- pyridinyl) methyl]thio} -1H-benzimidazole (II), empirical formula is C14H15FN3OS. Reagent 1: compound (II). Reagent 2: m-chlorobenzoic acid. Reaction conditions: isolation as a free form or as a salt. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 8 cl, 3 tbl
| Title |
Year |
Author |
Number |
| 5-FLUORO-2-{[(4-CYCLOPROPYLMETHOXY-2-PYRIDINYL)METHYL]SULFINYL}-1H-BENZIMIDAZOLE OR ITS PHYSIOLOGICALLY ACCEPTABLE SALT, PHARMCOMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS |
1989 |
- Arne Uljuf Brendstrem[Se]
- Per Lennart Lindberg[Se]
- Gunnel' Ehlisabet Sjunden[Se]
|
RU2073676C1 |
| 5-CHLORO-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL)- 1H-BENZIMIDAZOLE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION AND 5-CHLORO-2-[(3,4-DIMETHOXY-2- PYRIDINYL)METHYL)THIO]-1H-BENZIMIDAZOLE |
1989 |
- Arne Uljuf Brendstrem[Se]
- Per Lennart Lindberg[Se]
- Karl Ingemar Starke[Se]
- Gunnel' Ehlisabet Sjunden[Se]
|
RU2070199C1 |
| DERIVATIVES OF BENZIMIDAZOLE AND METHOD PRODUCTION THEREOF |
1987 |
- Tomas Ber'E Al'Minger[Se]
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- Khans Bungord[Dk]
- Per Lennart Lindberg[Se]
- Gunnel Ehlizabet Sunden[Se]
|
RU2062778C1 |
| OPTICALLY PURE Na, Mg, Li, K OR Ca SALTS OF (-)-5-METHOXY-2-[[(4- -METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZ-IMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON SAID AND INTERMEDIATE COMPOUND |
1994 |
- Per Lennart Lindberg
- Sverker Von Unge
|
RU2137766C1 |
| METHOD OF SYNTHESIS OF 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL- 2-PYRIDINYL)- METHYL]-SULFINYL]-1H-BENZIMIDAZOLE |
1996 |
- Gustavsson Anders
- Kellstrem Oke
|
RU2166502C2 |
| IMPROVED METHOD OF SYNTHESIS OF 5-METHOXY-2-[(4-METHOXY-3,5-DIMETHYL-2- PYRIDYL)METHYL]SULFINYL-1H-BENZIMIDAZOLE |
1999 |
- Khafner Milach Natasha
- Ereb Dar'Ja
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RU2197486C2 |
| DERIVATIVES OF BENZIMIDAZOLE AND PHARMACEUTICAL COMPOSITIONS COMPRISING PRODRUG OF PROTON PUMP INHIBITOR |
1999 |
- Gehrst Majkl E.
- Sehchs Dzhorzh
- Shin Dzhej Mu
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RU2232159C2 |
| BENZIMIDAZOLE DERIVATIVE |
2006 |
- Mijazava Sukhei
- Sinoda Masanobu
- Kavakhara Tetsuja
- Vatanabe Nobukhisa
- Kharada Khitosi
- Iida Daisuke
- Terauti Khiroki
- Nagakava Dzuniti
- Fudzisaki Khideaki
- Kubota Atsukhiko
- Ueda Masato
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RU2409573C2 |
| ALKOXY-SUBSTITUTED BENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL PREPARATIONS COMPRISING THEREOF AND METHOD FOR THEIR USING |
2000 |
- Uittl Robert R.
- Sanchilio Frederik D.
- Stouehll Grehjson Uoker
- Dzhenkins Duglas Dzhon
- Uittol Linda
- Mejer Glenn Alan
- Fontana Stiven A.
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RU2263673C2 |
| SOLID MEDICINAL FORMULA FOR ORAL ADMINISTRATION |
1992 |
- Kurt Ingmar Levgren[Se]
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- Mitsuru Jasumura[Jp]
- Satosi Morigaki[Jp]
- Minoru Oda[Jp]
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RU2095054C1 |
