FIELD: organic chemistry, chemical technology. SUBSTANCE: 3-aminodiphenylamine is treated with chlorocarbonic acid ethyl ester in two-phase system toluene-sodium hydrocarbonate an aqueous solution. After reaction termination water and toluene excess were removed from reaction mass and sulfur and iodine were added to the obtained mass. After thionating reaction termination suspension of reaction product is fed to acylation with 3-chloropropionyl chloride. Product of this stage is crystallized and then treated with diethylamine and then - with hydrogen chloride and the end product is isolated. The yield of 10-(3-diethylaminopropinyl)-phenothiazine carbamic-2 acid ethyl ester hydrochloride is 43.3% (as measured for the parent 3-aminodiphenylamine), m. p. is 200-202 C. The synthesized compound is used for treatment of myocardium infarction and arhythmia. EFFECT: simplified technology, improved safety.
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