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2 159 771

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Application

99110951/04, 1999-05-20

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Start date

1999-05-20

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Actual filing date

1999-05-20

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Published

2000-11-27

(72)

Inventor

Nikitenkova L.P.Shner V.F.Antonova T.S.Khokhlova V.M.Petrunina T.I.Vanin G.D.Salov B.V.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Rf

METHOD OF PREPARING 10-(3-MORPHOLYLPROPIONYL)PHENOTHIAZINE-2-CARBAMIC ACID ETHYL ESTER HYDROCHLORIDE Russian patent published in 2000 - IPC

Abstract RU 2159771 C1

FIELD: organic synthesis. SUBSTANCE: product, useful in treatment of cardiac infarctum, is prepared by interaction of 10- (3-chlorolpropionyl)phenothiazine-2-carbamic acid ethyl ester with morpholine to give free base, which is treated with hydrochloric acid to form hydrochloride. Method is distinguished by that free-base intermediate is crystallized directly from reaction mixture and filtered off before hydrochloric acid treatment. EFFECT: increased yield to 72,5 % and significantly simplified synthetic procedure.

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RU 2 159 771 C1

Authors

Nikitenkova L.P.

Shner V.F.

Antonova T.S.

Khokhlova V.M.

Petrunina T.I.

Vanin G.D.

Salov B.V.

Dates

2000-11-27—Published

1999-05-20—Filed

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