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2 098 421

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C1

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IPC

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Application

97102649/04, 1997-02-21

(22)

Actual filing date

1997-02-21

(45)

Published

1997-12-10

(72)

Inventor

Kaletina N.I.Kokornikova O.F.Afanas'Ev Ju.I.Arzamastsev E.V.Rubinov G.E.Zakharova V.F.Bel'Tjukova A.G.Baryshnikov A.Ju.Kaletin G.I.

(73)

Holder

Moskovskaja Meditsinskaja Akademija Im.I.M.Sechenova

COMPLEXES OF COPPER (II) AND NICKEL (II) WITH 1-(β-HYDROXYETHYL)-2-METHYL-5-NITROIMIDAZOLE Russian patent published in 1997 - IPC

Abstract RU 2098421 C1

FIELD: organometallic compounds. SUBSTANCE: invention relates to new derivatives of 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole showing antibacterial, antitrichomoniasis, fungicidic and immunostimulating activities. Complex compounds are able to recovery metallo-ligand homeostasis. Invention claims complex compounds of 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole with salts of copper (II) and nickel (II) that show the enhanced activity with respect to E. coli, S. aureus, P. aeruginosa, C. albicans, Bac. subtilis, Bacter. fragilis, Bacter. aniformis as compared with that of metronidazol. EFFECT: broadened spectrum of effect, enhanced immune response. 21 tbl, 3 dwg

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RU 2 098 421 C1

Authors

Kaletina N.I.

Kokornikova O.F.

Afanas'Ev Ju.I.

Arzamastsev E.V.

Rubinov G.E.

Zakharova V.F.

Bel'Tjukova A.G.

Baryshnikov A.Ju.

Kaletin G.I.

Dates

1997-12-10—Published

1997-02-21—Filed

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